Three-step biogenetic type synthesis of recently isolated bioactive natural product
Luotonin F (1) with 38% overall yield has been described starting from the natural product pegamine
(4a) via PCC-oxidation, Friedländer condensation, and chromium trioxide-periodic acid
oxidation reactions.
pegamine - PCC-oxidation -
o-aminobenzaldehyde - Friedländer condensation - Luotonin F synthesis