Biogenetic Synthesis of Luotonin F

Santosh B. Mhaske; Narshinha P. Argade

doi:10.1055/s-2002-20047

SHORTPAPER

Biogenetic Synthesis of Luotonin F [1]

Santosh B. Mhaske, Narshinha P. Argade*
Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411 008, India
Fax: +91(20)5893153; e-Mail: argade@dalton.ncl.res.in;

Abstract

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Abstract

Three-step biogenetic type synthesis of recently isolated bioactive natural product Luotonin F (1) with 38% overall yield has been described starting from the natural product pegamine (4a) via PCC-oxidation, Friedländer condensation, and chromium trioxide-periodic acid oxidation reactions.

Key words

pegamine - PCC-oxidation - o-aminobenzaldehyde - Friedländer condensation - Luotonin F synthesis

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References

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